Description

Troponin I CAS NO 77108-40-8 is a specific isoform of the troponin complex, a key regulatory protein in cardiac and skeletal muscle contraction. Its primary commercial and clinical significance lies in its role as a highly sensitive and specific biomarker for cardiac muscle damage, particularly in the diagnosis of acute myocardial infarction. This makes it an essential component for the manufacturing of in-vitro diagnostic (IVD) reagents, immunoassay kits, and research-grade biochemicals. It is therefore critical for diagnostic manufacturers, clinical research organizations, and biotechnology companies focused on cardiovascular disease.

Application

• Cardiac Biomarker Assay Development: Primary raw material for the production of antibodies, calibrators, and controls used in high-sensitivity troponin I (hs-cTnI) diagnostic tests.

• Immunoassay Kits: Core antigen for ELISA (Enzyme-Linked Immunosorbent Assay), CLIA (Chemiluminescent Immunoassay), and other immunodiagnostic platforms.

• Clinical Research & Drug Discovery: Used as a standard in studies investigating myocardial injury, cardiotoxicity of new pharmaceuticals, and the pathophysiology of heart diseases.

• Quality Control & Calibration: Serves as a reference standard for the validation and calibration of automated clinical chemistry analyzers in hospital and reference laboratories.

• Antibody Production: Critical immunogen for generating monoclonal and polyclonal antibodies with high specificity for human cardiac troponin I.

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  | Product Name | Troponin I |
  | CAS No. | 77108-40-8 |
  | Molecular Formula | Contact for details |
  | Molecular Weight | ~23.9 kDa (Cardiac Isoform) |
  | Synonyms | Cardiac Troponin I; cTnI; TNNI3; Troponin I, cardiac muscle; Human cardiac troponin I; Troponin I (cardiac); cTn-I; Cardiac-specific troponin I |
  | EINECS | Contact for details |

  Quality Control

  Our Troponin I is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical diagnostic applications. Each lot is characterized for identity, purity, and biological activity. Certificates of Analysis (COA) are provided, detailing specifications such as purity by HPLC, immunoreactivity, and absence of key interferents. Production can adhere to relevant ISO 13485 standards for IVD raw materials upon request.

  Storage

  Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot into working volumes upon first thaw to maintain optimal activity.

  Specification

  Item	Specification
  Appearance	White to off-white lyophilized powder
  Identification (Immunoassay)	Positive reactivity with anti-cardiac Troponin I antibodies
  Purity (SDS-PAGE)	≥ 95%
  Purity (HPLC)	≥ 90%
  Immunological Activity	Fully reactive in standard cTnI assay format
  Endotoxin	< 1.0 EU/μg
  Solubility	Soluble in appropriate aqueous buffers

  Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.**