Description

H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Oh is a synthetic heptapeptide with the sequence Tyr-Gly-Gly-Phe-Leu-Arg-Arg, representing a key fragment of the dynorphin A opioid peptide family. This compound is of significant interest in advanced biochemical and pharmacological research due to its role in studying opioid receptor interactions and signal transduction pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, pain management research, and peptide-based drug discovery.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies investigating κ-opioid receptor (KOR) function and dynorphinergic systems.
• Pharmacological Assay Development: Serves as a critical ligand in competitive binding assays and functional tests (e.g., cAMP accumulation, GTPγS binding) to screen and characterize novel opioid compounds.
• Biochemical Standard: Employed as a high-purity calibrant in analytical techniques such as HPLC and mass spectrometry for peptide quantification and method validation.
• Drug Discovery & Development: Acts as a lead compound or structural template for the design and synthesis of new peptide analogs with potential therapeutic applications.
• Academic & Institutional Research: Supports fundamental studies on pain mechanisms, addiction, stress responses, and neuropsychiatric disorders.

Basic Information

Item	Details
Product Name	H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Oh
CAS No.	77101-32-7
Molecular Formula	C41H64N14O10
Molecular Weight	889.04 g/mol
Synonyms	Dynorphin A (1-7); Tyr-Gly-Gly-Phe-Leu-Arg-Arg; Dynorphin A 1-7; Dynorphin A(1-7) heptapeptide; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-OH; Leu-enkephalin-Arg-Arg; [Arg6,Arg7]-Leu-Enkephalin; YGGFLRR
EINECS	Contact for details

Quality Control

Our H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.