Description

Cyclo(Glycyl-Phenylalanyl-Prolyl-N(Beta)-(n-Maleoylglycyl)-Alpha,β-Diaminopropanoyl) CAS NO 77087-68-4 is a specialized synthetic peptide derivative featuring a maleimide functional group, making it a critical intermediate for advanced bioconjugation and pharmaceutical research. Its core value lies in enabling the site-specific covalent attachment of biomolecules, such as antibodies or proteins, to other entities like drug payloads, polymers, or surfaces. This compound is essential for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and targeted drug delivery systems, where precise and stable molecular linkages are required.

Application

• Bioconjugation Reagent: Primary use for site-specific covalent coupling of peptides, proteins, or antibodies to carriers, labels, or solid supports via the maleimide-thiol chemistry.
• Antibody-Drug Conjugate (ADC) Development: Serves as a key chemical linker for attaching cytotoxic drugs to monoclonal antibodies in targeted cancer therapy research.
• Diagnostic Reagent Synthesis: Used in the production of enzyme-linked immunosorbent assay (ELISA) kits and other immunoassays by conjugating detection enzymes to antibodies.
• Peptide Therapeutics: Acts as a building block or functionalized intermediate in the synthesis of novel peptide-based pharmaceutical compounds.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, or chromatography media with bioactive peptides for specific capture or detection.
• Polymer-Peptide Hybrids: Facilitates the creation of smart biomaterials and drug delivery vehicles by linking therapeutic peptides to biodegradable polymers.

Basic Information

Item	Details
Product Name	Cyclo(Glycyl-Phenylalanyl-Prolyl-N(Beta)-(n-Maleoylglycyl)-Alpha,β-Diaminopropanoyl)
CAS No.	77087-68-4
Molecular Formula	C28H32N6O8
Molecular Weight	580.59 g/mol
Synonyms	Cyclo(Gly-Phe-Pro-N(β)-(N-Maleoylglycyl)-α,β-diaminopropanoyl); Maleimide-functionalized cyclic peptide; c(GFP-Mal-Dap); Cyclic GFF-Maleimide Conjugate; N-Maleoylglycyl-α,β-diaminopropanoic acid cyclic peptide derivative; 3-Maleimidopropionyl-Gly-Phe-Pro cyclic peptide; Bioconjugation linker peptide; CAS 77087-68-4
EINECS	Contact for details

Quality Control

Our Cyclo(Glycyl-Phenylalanyl-Prolyl-N(Beta)-(n-Maleoylglycyl)-Alpha,β-Diaminopropanoyl) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification, to ensure it meets the exacting standards required for research and biopharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term stability, consider storage desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.