Description

Enkephalin-Leu, (Ala(2)-Cl-Phe(4))- is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin. This compound is of significant interest for advanced research in neurobiology and pharmacology, particularly in the study of opioid receptor interactions and signal transduction pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, pain management research, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A critical tool for investigating the structure-activity relationships (SAR) of opioid peptides and their binding affinity to delta (δ) and mu (μ) opioid receptors.
• Pharmacological Studies: Used in in vitro and in vivo assays to study analgesic pathways, tolerance mechanisms, and the physiological effects of opioid receptor modulation.
• Drug Discovery & Development: Serves as a reference standard or a lead compound in the design and screening of new analgesic drugs with potentially improved efficacy or reduced side-effect profiles.
• Biochemical Analysis: Employed in competitive binding assays, receptor autoradiography, and other techniques to quantify receptor density and ligand affinity.
• Academic Research: Fundamental research in universities and institutes focusing on neuropeptides, neurotransmission, and the central nervous system.

Basic Information

Product Name	Enkephalin-Leu, (Ala(2)-Cl-Phe(4))-
CAS No.	77062-77-2
Molecular Formula	C33H44ClN7O8
Molecular Weight	702.20 g/mol
Synonyms	[D-Ala2, 4-Cl-Phe4]-Leu-Enkephalin; [D-Ala2, p-Cl-Phe4]-Leu-Enkephalin; [D-Ala2,4-Cl-Phe4]-Leu-Enkephalin; [D-Ala2,4'-Cl-Phe4]Leu-enkephalin; H-Tyr-D-Ala-Gly-(4-Cl)Phe-Leu-OH; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-Amino-2-(4-chlorophenyl)acetyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoic acid; pCl-DPDPE (commonly associated analog); Delta opioid receptor selective peptide analog.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer this peptide in high-purity grades suitable for research applications, with quality verified by advanced analytical techniques. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, acetic acid; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.