Description

Enkephalin, Arg(2)-Leu(5)- is a synthetic peptide analog of the endogenous opioid peptide enkephalin, specifically modified at the second and fifth amino acid positions. This compound is of significant interest in neuroscience and pharmaceutical research for its role in studying opioid receptor interactions and pain modulation pathways. It is primarily utilized by research institutions and pharmaceutical developers focused on neurobiology, analgesic drug discovery, and peptide-based therapeutics. The product is supplied as a high-purity material to ensure reliable and reproducible experimental results.

Application

• Neuroscience Research: As a tool compound for investigating the function and binding characteristics of delta and mu opioid receptors.
• Pharmacological Studies: Used in vitro and in vivo to study pain perception, analgesia, and the physiological effects of enkephalin analogs.
• Drug Discovery & Development: Serves as a reference standard or lead compound in the design and screening of novel analgesic and neuroprotective agents.
• Biochemical Assays: Employed in receptor binding assays, signal transduction studies, and enzyme interaction tests to elucidate metabolic pathways.
• Academic & Institutional Research: Fundamental research into the endogenous opioid system, neurotransmitter release, and peptide hormone activity.

Basic Information

Product Name	Enkephalin, Arg(2)-Leu(5)-
CAS No.	76939-27-0
Molecular Formula	C34H52N12O8
Molecular Weight	756.86 g/mol
Synonyms	Arg(2)-Leu(5)-Enkephalin; [Arg2, Leu5]-Enkephalin; H-Tyr-Arg-Gly-Phe-Leu-OH; YRGL; Opioid peptide analog; Leu5-Enkephalin, Arg2-; Tyr-Arg-Gly-Phe-Leu
EINECS	Contact for details

Quality Control

Our Enkephalin, Arg(2)-Leu(5)- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Quality assurance protocols include advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.