Description

Conotoxin Gii is a highly specific and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is a critical research tool for studying voltage-gated sodium channels (NaV), particularly the NaV1.4 subtype, due to its selective inhibitory action. It is primarily utilized by pharmaceutical researchers, neuroscientists, and toxicologists in academic, biotechnology, and pharmaceutical development settings to investigate channel function, pain pathways, and novel therapeutic targets.

Application

• Neuroscience Research: A selective probe for blocking and characterizing skeletal muscle voltage-gated sodium channels (NaV1.4) in electrophysiological studies.
• Pharmacology & Drug Discovery: Used in high-throughput screening assays to identify and evaluate novel analgesic compounds or sodium channel modulators.
• Toxicology Studies: Serves as a reference standard for understanding the mechanism of action of conotoxins and for assessing biological activity in related venoms.
• Biochemical Reagent: Employed in ligand-binding experiments and structure-activity relationship (SAR) studies to map channel binding sites.
• Academic & Industrial R&D: Essential for basic research into ion channel physiology, neuropathic pain mechanisms, and the development of channel-specific therapeutics.

Basic Information

Product Name	Conotoxin Gii
CAS No.	76862-66-3
Molecular Formula	C96H146N30O28S6
Molecular Weight	~2280.7 g/mol
Synonyms	μ-Conotoxin GII; μ-Conotoxin GIIA; Mu-conotoxin GII; Geographutoxin II; GII Conotoxin; Conotoxin μ-GII; μ-CTx GII; Sodium channel blocker μ-conotoxin GII
EINECS	Contact for details

Quality Control

Our Conotoxin Gii is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and bioactivity. We adhere to rigorous internal quality protocols to guarantee batch-to-batch consistency and reliability for your critical research needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Single-Chain Proportion (HPLC)	≥ 90%
Biological Activity	Confirmed by functional assay (e.g., NaV1.4 inhibition)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.