Description

α-Conotoxin Gi is a selective and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is of significant value in neuroscience research as a highly specific antagonist for nicotinic acetylcholine receptors (nAChRs). It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies for studying receptor function, neuronal signaling pathways, and as a potential pharmacological tool in drug discovery.

Application

• Neuroscience Research: As a specific probe for studying the structure and function of neuronal nicotinic acetylcholine receptors (nAChRs).
• Pharmacological Studies: Used to investigate receptor-ligand interactions, signal transduction, and ion channel modulation.
• Drug Discovery Platform: Serves as a lead compound or template for developing novel therapeutics targeting neurological disorders and chronic pain.
• Biochemical Assay Development: Employed in the development of high-throughput screening assays for identifying new receptor modulators.
• Academic & Clinical Research: Essential tool for fundamental research into synaptic transmission, neuropharmacology, and neurophysiology.

Basic Information

Product Name	α-Conotoxin Gi
CAS No.	76862-65-2
Molecular Formula	C58H86N18O18S5
Molecular Weight	1419.7 g/mol
Synonyms	α-Conotoxin GI; Conotoxin GI; α-Conotoxin GI; GI Conotoxin; α-GI; GI; Mu-Conotoxin GI; Acetylcholine receptor inhibitor GI; SNX-124; ω-Conotoxin GVIA (structurally related class); 76862-65-2; UNII-3KX376GY7L
EINECS	Contact for details

Quality Control

Our α-Conotoxin Gi is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Stability studies are conducted to guarantee product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot into working solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (Karl Fischer)	≤ 5.0%
Solubility	Soluble in water or aqueous buffers
Biological Activity	Specified activity confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.