Description

1-tert-Butylthymine is a specialized thymine derivative where a tert-butyl group is substituted at the N1 position. This modification is significant as it introduces steric bulk and alters the electronic properties of the nucleobase, making it a valuable building block in organic synthesis and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds and studying structure-activity relationships.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel nucleoside analogs, antiviral agents, and other therapeutic compounds.
• Agrochemical Research: Used in the synthesis of experimental pesticides and herbicides where modified nucleobase structures are explored for bioactivity.
• Chemical Biology Probe: Acts as a modified base in oligonucleotide synthesis for studying DNA-protein interactions, enzyme mechanisms, and as a molecular probe.
• Organic Synthesis Building Block: Employed in medicinal chemistry for the preparation of complex molecules, leveraging the tert-butyl group for steric directing or protective purposes.
• Material Science Research: Investigated as a component in the design of specialty polymers or supramolecular assemblies due to its hydrogen-bonding capabilities.

Basic Information

Product Name	1-tert-Butylthymine
CAS No.	76849-31-5
Molecular Formula	C9H14N2O2
Molecular Weight	182.22 g/mol
Synonyms	1-(1,1-Dimethylethyl)thymine; 1-(tert-Butyl)thymine; N-tert-Butylthymine; Thymine, 1-(1,1-dimethylethyl)-; 1-tert-Butyl-5-methyl-2,4(1H,3H)-pyrimidinedione; 5-Methyl-1-(2-methyl-2-propanyl)-2,4(1H,3H)-pyrimidinedione; N1-tert-Butylthymine
EINECS	Contact for details

Quality Control

Our 1-tert-Butylthymine is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.