Description

L-Proline, 3,3-Dimethyl- is a non-proteinogenic, sterically hindered proline derivative characterized by the presence of two methyl groups at the 3-position of the pyrrolidine ring. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for introducing conformational constraints. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and asymmetric catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of constrained peptides and complex drug molecules targeting various therapeutic areas.
• Peptidomimetics Research: Used to induce specific secondary structures (e.g., turns, helices) in peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts in enantioselective synthesis.
• Biochemical Research: Employed in studies of enzyme inhibition, protein engineering, and as a probe for studying proline metabolism.
• Agrochemical Synthesis: An intermediate in the production of advanced, chiral crop protection agents.

Basic Information

Product Name	L-Proline, 3,3-Dimethyl-
CAS No.	76804-64-3
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(2S)-3,3-Dimethylpyrrolidine-2-carboxylic acid; 3,3-Dimethyl-L-proline; (S)-3,3-Dimethylproline; L-3,3-Dimethylproline; 3,3-Dimethyl-D-proline (enantiomer); 3,3-Dimethylproline; 2-Pyrrolidinecarboxylic acid, 3,3-dimethyl-, (2S)-
EINECS	Contact for details

Quality Control

Our L-Proline, 3,3-Dimethyl- is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including chiral purity verification, assay, and impurity profiling to ensure it meets high-purity standards suitable for research and pharmaceutical development. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.