Description

Somatostatin, 5-Methoxy-Trp(8)- is a synthetic analogue of the endogenous peptide hormone somatostatin, featuring a methoxy substitution at the tryptophan-8 position. This structural modification is designed to enhance metabolic stability and receptor binding affinity, making it a valuable research tool for studying somatostatin receptor (SSTR) signaling pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroendocrine research, metabolic studies, and the development of novel therapeutic agents.

Application

• Biomedical Research: Fundamental studies on the physiological roles of somatostatin and its receptor subtypes (SSTR1-5).
• Drug Discovery & Development: Serving as a reference compound or lead structure for designing new SSTR-targeting pharmaceuticals for conditions like acromegaly, neuroendocrine tumors, and diabetic retinopathy.
• Receptor Binding Assays: Used in competitive binding studies to characterize receptor affinity and selectivity of novel compounds.
• Signal Transduction Studies: Investigating the inhibition of hormone secretion (e.g., growth hormone, insulin, glucagon) and cellular proliferation mechanisms.
• In vitro & Ex vivo Models: Application in cell culture and tissue-based experiments to elucidate somatostatin's effects.
• Analytical Standard: Employed as a high-purity reference standard in chromatographic (HPLC, LC-MS) and spectroscopic analyses for quality control and method validation.

Basic Information

Product Name	Somatostatin, 5-Methoxy-Trp(8)-
CAS No.	76689-49-1
Molecular Formula	C76H104N18O19S2
Molecular Weight	1637.9 g/mol
Synonyms	5-Methoxy-D-Trp(8)-Somatostatin; [5-Methoxy-D-Trp8]-Somatostatin; Somatostatin (5-methoxy-D-tryptophan8-); D-Trp(5-MeO)8-Somatostatin; SRIF-14 (5-MeO-D-Trp8); Alamid; BIM 23014; Cyclo(Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp(5-MeO)-Lys-Thr-Phe-Thr-Ser-Cys)
EINECS	Contact for details

Quality Control

Our Somatostatin, 5-Methoxy-Trp(8)- is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the specific results for that lot. We can support development projects requiring compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in acetic acid, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.