Description

n-Ac-B-Endorphin Fragment 1-27, Human is a synthetic peptide fragment of the endogenous opioid peptide β-endorphin, featuring an N-terminal acetylation. This modification enhances its stability and makes it a critical research tool for studying opioid receptor interactions and signal transduction pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in neuroscience, pain management research, and peptide-based drug discovery.

Application

• Neuroscience Research: As a key ligand for investigating the binding affinity and functional activity of opioid receptors (primarily μ-opioid receptors) in vitro.
• Biochemical Assay Development: Serving as a standard or control in competitive binding assays, receptor activation studies, and high-throughput screening (HTS) platforms.
• Pain Pathway Studies: Used in experimental models to elucidate the mechanisms of endogenous pain modulation and the effects of peptide modifications.
• Pharmaceutical R&D: A reference compound in the design and development of novel analgesic peptides with improved stability and efficacy profiles.
• Cell Signaling Research: Probing intracellular signaling cascades initiated by opioid receptor activation in various cell lines.

Basic Information

Product Name	n-Ac-B-Endorphin Fragment 1-27, Human
CAS No.	76622-86-1
Molecular Formula	C140H220N34O42
Molecular Weight	3051.5 g/mol
Synonyms	N-Acetyl-β-Endorphin (1-27); Acetylated β-Endorphin (1-27), Human; N-Ac-β-Endorphin (1-27); [Acetyl]-β-Endorphin (1-27); β-Lipotropin (61-87), N-acetyl-; H-Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-OH (N-acetyl); Ac-β-EP (1-27)
EINECS	Contact for details

Quality Control

Our n-Ac-B-Endorphin Fragment 1-27, Human is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.