Description

Leucinostatin A is a naturally occurring non-ribosomal cyclic depsipeptide antibiotic isolated from the fungus *Acremonium* sp., exhibiting potent antifungal and antiprotozoal activity via inhibition of mitochondrial protein synthesis. It serves as a critical pharmacological tool for studying mitochondrial function, membrane permeability, and apoptosis mechanisms in eukaryotic cells. Researchers in academic laboratories, pharmaceutical R&D centers, and biotechnology companies rely on high-purity Leucinostatin A CAS NO 76600-38-9 for mechanistic studies, target validation, and early-stage antimicrobial discovery.

Application

• Investigation of mitochondrial electron transport chain disruption and ATP depletion in mammalian cell models
• Functional screening for compounds that induce selective cytotoxicity in drug-resistant fungal strains
• Tool compound for probing mitochondrial permeability transition pore (mPTP) opening dynamics
• Reference standard in LC-MS/MS method development for antifungal metabolite quantification
• Lead structure for semi-synthetic optimization targeting improved selectivity and reduced cytotoxicity
• In vitro evaluation of synergistic effects with conventional azole antifungals against *Candida* and *Aspergillus* species
• Cell-based assays for identifying modulators of autophagy and programmed cell death pathways
• Quality control reference material for natural product isolation workflows and fermentation process monitoring

Basic Information

Product Name	Leucinostatin A
CAS No.	76600-38-9
Molecular Formula	C54H85N11O15
Molecular Weight	1124.32 g/mol
Synonyms	Leucinostatin; Leucinostatin-A; Leucinostatin A (natural); NSC 132329; CI-920; FR-900452; Acremonium antibiotic A; Cyclo-(D-Leu-L-Ile-D-allo-Ile-L-Leu-D-Val-L-Val-D-Val-L-Leu-D-Val-L-Leu)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch of Leucinostatin A is verified for identity (HPLC retention time match, IR spectral overlay), assay (≥95.0% by HPLC), and impurity profile (individual unknown impurities ≤0.1%, total impurities ≤2.0%). Testing adheres to ICH Q2(R2) guidelines and supports research-grade applications under ISO 9001-certified quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent oxidation and degradation. Due to its hygroscopic nature, maintain low-humidity conditions (<30% RH) and minimize exposure to ambient air during handling.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard
Identification (IR)	Characteristic absorption bands consistent with depsipeptide structure
Assay (HPLC)	≥95.0%
Related Substances	Individual impurities ≤0.1%; Total impurities ≤2.0%
Residual Solvents	Meets ICH Q3C limits
Water Content (Karl Fischer)	≤5.0%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.