Description

Angiotensin I, Sar(1)-(S-Me)Cys(8)- is a synthetic, modified peptide analog of the endogenous hormone Angiotensin I. This compound is of significant value in biochemical and pharmacological research as a potent and selective tool for studying the renin-angiotensin system (RAS). It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers for applications in cardiovascular research, enzyme inhibition studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in studies of angiotensin-converting enzyme (ACE) and related peptidases.
• Pharmacological Studies: Serves as a reference standard and investigative tool for understanding the mechanisms of the renin-angiotensin system in hypertension and heart failure models.
• Drug Discovery & Development: A key intermediate or analog in the design and screening of new cardiovascular drugs targeting blood pressure regulation.
• Diagnostic Reagent Manufacturing: Utilized in the production of immunoassay kits and other diagnostic tests for measuring components of the RAS pathway.
• Enzyme Kinetics: Employed to determine kinetic parameters and inhibition constants (Ki) for ACE and other proteolytic enzymes.
• Cell Signaling Research: Investigates peptide-receptor interactions and downstream signaling cascades in vascular and renal tissues.

Basic Information

Product Name	Angiotensin I, Sar(1)-(S-Me)Cys(8)-
CAS No.	76500-12-4
Molecular Formula	C49H69N13O11S
Molecular Weight	1048.2 g/mol
Synonyms	[Sar1, (S-Me)Cys8]-Angiotensin I; Saralasin Acetate precursor; 1-Sarcosine-8-(S-methylcysteine)-angiotensin I; Angiotensin I (1-10) (human, horse) [Sar1, Cys(Me)8]-; Modified Angiotensin I; ACE Inhibitor Peptide Analog; H-Sar-Arg-Val-Tyr-Ile-His-Pro-Cys(Me)-His-Leu-OH
EINECS	Contact for details

Quality Control

Our Angiotensin I, Sar(1)-(S-Me)Cys(8)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by MS and NMR. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues, ensuring compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.