Description

n-Phosphopyridoxyl-L-Serine is a phosphorylated derivative of pyridoxal (vitamin B6) covalently linked to the amino acid L-serine, representing a key intermediate in vitamin B6 metabolism and enzyme cofactor biochemistry. This compound is of significant interest for research into enzymatic mechanisms, particularly those involving pyridoxal phosphate (PLP)-dependent enzymes like serine hydroxymethyltransferase. It serves as a critical biochemical tool and potential precursor for researchers and manufacturers in the pharmaceutical, diagnostic, and advanced life science sectors.

Application

• Biochemical Research: Used as a substrate, inhibitor, or mechanistic probe in studies of pyridoxal phosphate (PLP)-dependent enzymes.
• Pharmaceutical Intermediates: Serves as a sophisticated building block in the synthesis of novel drug candidates targeting metabolic pathways.
• Diagnostic Reagent Development: Employed in the formulation of enzymatic assay kits for clinical diagnostics and research.
• Enzymology Studies: Essential for investigating the catalytic cycle and substrate specificity of transaminases and other B6-dependent enzymes.
• Metabolite Standard: Acts as a high-purity reference standard in mass spectrometry and chromatography for metabolomics research.
• Nutritional Science Research: Used in studies exploring the complex metabolism and biological activity of vitamin B6 derivatives.

Basic Information

Product Name	n-Phosphopyridoxyl-L-Serine
CAS No.	76500-10-2
Molecular Formula	C11H15N2O9P
Molecular Weight	350.22 g/mol
Synonyms	O-Phosphopyridoxyl-L-serine; L-Serine, O-[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methyl hydrogen phosphate; Phosphopyridoxylserine; Pyridoxylphosphoserine; PLP-L-Serine; Vitamin B6 Phosphate Serine Derivative; 4-Pyridoxic Acid 5'-Phosphate Serine Ester (related structure)
EINECS	Contact for details

Quality Control

Our n-Phosphopyridoxyl-L-Serine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.