Description

2,3,5,6-Tetrafluoro-4-(Trifluoromethyl)Benzyl Bromide is a highly fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity of the benzyl bromide group combined with the electron-withdrawing and lipophilicity-enhancing properties of the perfluorinated aromatic system. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and specialty materials where fluorine substitution is strategically important.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the 2,3,5,6-tetrafluoro-4-(trifluoromethyl)benzyl moiety into drug candidates, potentially enhancing metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that leverage fluorine chemistry for improved efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Polymer & Resin Modification: Employed to incorporate fluorinated benzyl groups into polymers, imparting specific properties like chemical resistance or altered surface energy.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct complex fluorinated biaryl systems.
• Nucleophilic Substitution Scaffold: The benzyl bromide functionality is readily displaced by a wide range of nucleophiles, enabling rapid diversification of the fluorinated core.

Basic Information

Product Name	2,3,5,6-Tetrafluoro-4-(Trifluoromethyl)Benzyl Bromide
CAS No.	76437-40-6
Molecular Formula	C8H2BrF7
Molecular Weight	310.99 g/mol
Synonyms	α-Bromo-2,3,5,6-tetrafluoro-4-(trifluoromethyl)toluene; 4-(Bromomethyl)-1,2,3,5-tetrafluoro-6-(trifluoromethyl)benzene; (2,3,5,6-Tetrafluoro-4-trifluoromethylphenyl)methyl bromide; Pentafluorobenzyl Bromide derivative; Perfluorinated Benzyl Bromide; TFMBzBr; 76437-40-6; 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluoro-4-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of research and process development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.