Description

L-Methionine, [Methyl-3H] is a high-specific-activity, tritium-labeled derivative of the essential sulfur-containing amino acid L-Methionine. This radiolabeled compound is a critical tool for metabolic pathway tracing, protein synthesis studies, and autoradiography in advanced biochemical and pharmacological research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers requiring precise tracking of methionine incorporation and methylation processes.

Application

• Biochemical Tracer Studies: Used to investigate methionine metabolism, transmethylation pathways, and homocysteine recycling in cell culture and animal models.
• Protein Synthesis & Turnover Research: Essential for pulse-chase experiments to measure rates of protein synthesis, degradation, and post-translational modifications.
• Autoradiography & Imaging: Serves as a radioligand in histological and whole-body autoradiography to visualize methionine uptake and distribution in tissues.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to trace the metabolic fate of methionine-containing compounds or drugs affecting methionine cycles.
• Oncology Research: Applied in studies of tumor metabolism, as many cancer cells exhibit altered methionine dependence and uptake (the "Hoffman effect").
• Neurochemical Research: Used in studies of myelin synthesis and neurological disorders where methionine metabolism is implicated.

Basic Information

Product Name	L-Methionine, [Methyl-3H]
CAS No.	76408-00-9
Molecular Formula	C5H11NO2S (with 3H label on the methyl group)
Molecular Weight	~149.21 g/mol (unlabeled); Specific activity provided per batch
Synonyms	(S)-2-Amino-4-((3H)methylthio)butyric acid; L-2-Amino-4-(methyl-3H-thio)butyric acid; Tritiated L-Methionine; [Methyl-3H]-L-Methionine; L-Methionine(methyl-3H); H-3-L-Methionine; Radioactive L-Methionine
EINECS	Contact for details

Quality Control

Every batch of L-Methionine, [Methyl-3H] is manufactured and analyzed under strict quality systems. Radiochemical purity and chemical purity are determined via advanced analytical methods including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is supplied with each shipment, detailing specific activity (Ci/mmol or GBq/mmol), concentration, solvent, radiochemical purity (typically >97%), and analytical chromatograms. Our quality commitment ensures reproducibility and reliability for your long-term studies.

Storage

Preserve in the original manufacturer's vial as a solution in a tightly closed container, protected from light. Store frozen at or below -20°C. For long-term storage, maintain at -70°C to -80°C. The product is strictly light-sensitive (protect from all light exposure). Always follow appropriate radiation safety protocols and local regulations for handling, storage, and disposal of radioactive materials.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC, TLC)	Conforms to reference standard
Specific Activity	Customizable; 70-85 Ci/mmol typical range
Concentration	1 mCi/mL (37 MBq/mL) typical in aqueous ethanol
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water (7:3 v/v) or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.