Description

Ethyl 5-Hydroxy-7-Oxo-2-Phenyl-8-(Prop-2-Ynyl)-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and novel chemical entities. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and development, particularly for therapeutic areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of target drug molecules, especially in oncology and antiviral research pipelines.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical libraries for high-throughput screening.
• API Synthesis: Employed in the production route of complex Active Pharmaceutical Ingredients (APIs) that incorporate the dihydropyridopyrimidine pharmacophore.
• Biochemical Tool Compound: Utilized in biochemical assays to study enzyme inhibition or modulation of specific biological pathways.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up development.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	Ethyl 5-Hydroxy-7-Oxo-2-Phenyl-8-(Prop-2-Ynyl)-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	76361-09-6
Molecular Formula	C21H17N3O4
Molecular Weight	375.38 g/mol
Synonyms	Ethyl 5-hydroxy-7-oxo-2-phenyl-8-(prop-2-yn-1-yl)-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate; 8-Propargyl-5-hydroxy-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; 76361-09-6; Ethyl 8-propargyl-5-hydroxy-2-phenyl-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate; 5-Hydroxy-7-oxo-2-phenyl-8-(2-propynyl)-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-7-Oxo-2-Phenyl-8-(Prop-2-Ynyl)-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided and available upon request. We support development with custom purity grades to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.