Description

Ethyl 5-Hydroxy-8-Isopropyl-2-(Methylthio)-7-Oxo-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and anti-infectives. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted therapies.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Acts as a versatile precursor for further functionalization to create libraries of novel pyridopyrimidine derivatives.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.

Basic Information

Product Name	Ethyl 5-Hydroxy-8-Isopropyl-2-(Methylthio)-7-Oxo-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	76360-86-6
Molecular Formula	C15H17N3O4S
Molecular Weight	335.38 g/mol
Synonyms	Ethyl 5-hydroxy-8-(propan-2-yl)-2-(methylsulfanyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate; 8-Isopropyl-2-(methylthio)-5-hydroxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester; Pyrido[2,3-d]pyrimidine-6-carboxylic acid derivative; CAS 76360-86-6; Advanced Pyridopyrimidine Intermediate; Light-sensitive Pyridopyrimidine Ester
EINECS	Contact for details

Quality Control

Our production of Ethyl 5-Hydroxy-8-Isopropyl-2-(Methylthio)-7-Oxo-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.