Description

Ethyl 5-Hydroxy-8-Methyl-2-(Methylthio)-7-Oxo-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially within the pyridopyrimidine chemical class.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new chemical entities (NCEs).
• Kinase Inhibitor Development: Used in the research and development of selective kinase inhibitors for oncology and inflammatory disease applications.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.
• Process Chemistry & Scale-Up: Employed in the optimization and pilot-scale production of active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	Ethyl 5-Hydroxy-8-Methyl-2-(Methylthio)-7-Oxo-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	76360-81-1
Molecular Formula	C₁₃H₁₃N₃O₄S
Molecular Weight	307.33 g/mol
Synonyms	Ethyl 5-hydroxy-8-methyl-2-(methylthio)-7-oxo-7,8-dihydro-2H-pyrido[2,3-d]pyrimidine-6-carboxylate; 7,8-Dihydro-5-hydroxy-8-methyl-2-(methylthio)-7-oxopyrido[2,3-d]pyrimidine-6-carboxylic Acid Ethyl Ester; 2H-Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 7,8-dihydro-5-hydroxy-8-methyl-2-(methylthio)-7-oxo-, ethyl ester; CAS 76360-81-1
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-8-Methyl-2-(Methylthio)-7-Oxo-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.