Description

Ethyl 5-Hydroxy-7-Oxo-2,8-Diphenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyridopyrimidine class of heterocyclic compounds. This compound matters as a critical building block for the research and development of novel therapeutic agents, offering a structurally complex scaffold for medicinal chemistry. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on oncology, antiviral, and other targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Kinase Inhibitor Development: The pyridopyrimidine core is a privileged structure in the design of protein kinase inhibitors for cancer therapy.
• Academic Research: Employed in universities and research institutes for studying heterocyclic chemistry and novel synthetic pathways.
• Custom Synthesis: A starting material for the contract manufacturing of proprietary compounds for biotechnology clients.
• Chemical Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	Ethyl 5-Hydroxy-7-Oxo-2,8-Diphenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	76360-75-3
Molecular Formula	C24H19N3O4
Molecular Weight	413.43 g/mol
Synonyms	Ethyl 5-hydroxy-7-oxo-2,8-diphenyl-7,8-dihydro-5H-pyrido[2,3-d]pyrimidine-6-carboxylate; 5H-Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 7,8-dihydro-5-hydroxy-7-oxo-2,8-diphenyl-, ethyl ester; Ethyl 5-hydroxy-7-oxo-2,8-diphenyl-5,7,8,9-tetrahydropyrido[2,3-d]pyrimidine-6-carboxylate; 76360-75-3; AI3-52511; SCHEMBL2182691; ZINC000004143756.
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-7-Oxo-2,8-Diphenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere if long-term storage is required.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.