Description

Ethyl 5-Hydroxy-8-(2-Methoxyethyl)-7-Oxo-2-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the dihydropyridopyrimidine class of heterocyclic compounds. This compound is of significant commercial value as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. It is essential for research and development chemists, process development scientists, and manufacturers in the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry: Serves as a key starting material (KSM) or an advanced intermediate in the scale-up and optimization of API manufacturing processes.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for custom synthesis projects and clinical trial material production.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and novel synthetic methodologies.

Basic Information

Product Name	Ethyl 5-Hydroxy-8-(2-Methoxyethyl)-7-Oxo-2-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	76360-60-6
Molecular Formula	C19H19N3O5
Molecular Weight	369.37 g/mol
Synonyms	Ethyl 5-hydroxy-8-(2-methoxyethyl)-7-oxo-2-phenyl-7,8-dihydro-6H-pyrido[2,3-d]pyrimidine-6-carboxylate; 7,8-Dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid, 5-hydroxy-8-(2-methoxyethyl)-7-oxo-2-phenyl-, ethyl ester; 76360-60-6; Ethyl 5-hydroxy-8-(2-methoxyethyl)-7-oxo-2-phenyl-7,8-dihydro-6H-pyrido[2,3-d]pyrimidine-6-carboxylate; Dihydropyridopyrimidine derivative
EINECS	Contact for details

Quality Control

Our Ethyl 5-Hydroxy-8-(2-Methoxyethyl)-7-Oxo-2-Phenyl-7,8-Dihydropyrido[2,3-D]Pyrimidine-6-Carboxylate is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR, and mass spectrometry for structural confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.