Description

Dl-2-Amino-5-Phosphonopentanoic Acid CAS NO 76326-31-3 is a potent and selective competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, a key subtype of glutamate receptors in the central nervous system. This compound is a critical research tool for neuroscientists studying excitatory neurotransmission, synaptic plasticity, and the pathophysiology of neurological disorders. It is essential for academic research, pharmaceutical R&D, and diagnostic applications focused on neurodegenerative diseases, stroke, and chronic pain mechanisms.

Application

• Neuroscience Research: Used as a selective NMDA receptor antagonist to study glutamatergic signaling, long-term potentiation (LTP), and excitotoxicity in cellular and animal models.
• Pharmaceutical Development: Serves as a reference standard and pharmacological tool in the discovery and validation of novel neuroprotective agents and neuromodulators.
• Biochemical Assays: Employed in in vitro receptor binding studies and enzyme inhibition assays to characterize compound interactions with the NMDA receptor complex.
• Disease Mechanism Studies: Facilitates research into the molecular mechanisms underlying conditions such as Alzheimer's disease, Parkinson's disease, epilepsy, and ischemic brain injury.
• Academic & Clinical Research: A standard reagent in university laboratories and clinical research institutions for investigating synaptic function and neuronal cell death.

Basic Information

Product Name	Dl-2-Amino-5-Phosphonopentanoic Acid
CAS No.	76326-31-3
Molecular Formula	C5H12NO5P
Molecular Weight	197.13 g/mol
Synonyms	DL-AP5; DL-2-Amino-5-phosphonovaleric acid; DL-APV; (±)-2-Amino-5-phosphonopentanoic acid; (RS)-2-Amino-5-phosphonopentanoic acid; DL-2-Amino-5-phosphonopentanoate; NMDA receptor antagonist AP5; 2-Amino-5-phosphonopentanoic acid racemic mixture
EINECS	Contact for details

Quality Control

Our Dl-2-Amino-5-Phosphonopentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive biomedical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 103.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.