Description

Fmoc-n-ε-Trifluoroacetyl-L-Lysine is a protected derivative of the essential amino acid L-lysine, specifically engineered for advanced peptide synthesis. This compound matters because it provides orthogonal protection for the lysine side chain, enabling the precise, sequential assembly of complex peptides and proteins in solid-phase and solution-phase methodologies. It is a critical building block needed by research institutions and pharmaceutical companies developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of lysine residues with protected side-chain functionality.
• Solution-Phase Peptide Synthesis: Used in the synthesis of peptide fragments and small cyclic peptides where selective deprotection is required.
• Pharmaceutical Research: Serves as a crucial building block in the development of novel peptide-based drugs, hormones, and vaccines.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR) of peptide analogs.
• Biochemical Research: Used in studies of enzyme substrates, inhibitors, and the synthesis of custom peptides for biological assays.

Basic Information

Product Name	Fmoc-n-ε-Trifluoroacetyl-L-Lysine
CAS No.	76265-69-5
Molecular Formula	C23H23F3N2O6
Molecular Weight	480.44 g/mol
Synonyms	Fmoc-Lys(Tfa)-OH; N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N2-(trifluoroacetyl)-L-lysine; Fmoc-Nε-trifluoroacetyl-L-lysine; (2S)-6-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-[(2,2,2-trifluoroacetyl)amino]hexanoic acid; Fmoc-Lys(Nε-TFA)-OH; Nα-Fmoc-Nε-TFA-L-lysine; Fmoc-Lys(TFA)-OH; Fmoc-Nε-TFA-L-Lys-OH
EINECS	Contact for details

Quality Control

Our Fmoc-n-ε-Trifluoroacetyl-L-Lysine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.