Description

3,5-Diiodo-L-Tyrosine Hydrazide is a specialized iodinated tyrosine derivative, a key intermediate in the synthesis of complex bioactive molecules. This compound matters for its role as a versatile building block in pharmaceutical research and development, particularly for creating thyroid hormone analogs and radiopharmaceutical precursors. It is needed by research institutions, pharmaceutical companies, and fine chemical manufacturers focused on endocrinology, diagnostic imaging, and novel therapeutic agent synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of thyroid hormone analogs and receptor ligands.
• Radiopharmaceutical Precursor: Used in research for developing iodine-123 or iodine-131 labeled compounds for diagnostic imaging and therapy.
• Biochemical Research: Serves as a tool compound in studies of tyrosine kinase activity, iodination pathways, and hormone metabolism.
• Peptide Modification: Enables the site-specific introduction of iodine atoms into peptide chains for structure-activity relationship (SAR) studies.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Organic Synthesis: The reactive hydrazide group allows for further chemical transformations, such as the formation of hydrazones and other heterocycles.

Basic Information

Product Name	3,5-Diiodo-L-Tyrosine Hydrazide
CAS No.	76203-88-8
Molecular Formula	C9H10I2N3O3
Molecular Weight	461.00 g/mol
Synonyms	L-Tyrosine, 3,5-diiodo-, hydrazide; DIH; 3,5-Diiodotyrosine hydrazide; (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanehydrazide; 3,5-Diiodo-4-hydroxyphenylalanine hydrazide; 3,5-Diiodo-L-tyrosine hydrazide; H-DIIT-OH-NHNH2
EINECS	Contact for details

Quality Control

Our 3,5-Diiodo-L-Tyrosine Hydrazide is manufactured under a quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, containers must be sealed immediately after use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.