Description

N(Alpha)-Phosphorylvalyltryptophan is a specialized, chemically modified dipeptide derivative that integrates a phosphoryl group onto the N-terminus of a valyl-tryptophan backbone. This unique structure makes it a valuable synthetic intermediate and research tool for studying peptide phosphorylation, signal transduction pathways, and enzyme inhibition. It is primarily utilized by research scientists and process developers in the pharmaceutical and biotechnology sectors for drug discovery, proteomics research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: As a key synthetic intermediate or reference standard in the discovery of novel kinase inhibitors and phosphopeptide-based therapeutics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate phosphorylation mechanisms and signal transduction cascades.
• Proteomics & Peptide Chemistry: Serves as a building block for the solid-phase or solution-phase synthesis of complex, phosphorylated peptides for structural and functional studies.
• Academic Research: Employed in university and institutional labs for fundamental research in biochemistry, medicinal chemistry, and cell biology.
• Process Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) that incorporate phosphorylated amino acid motifs.

Basic Information

Product Name	N(Alpha)-Phosphorylvalyltryptophan
CAS No.	76166-64-8
Molecular Formula	C17H22N3O7P
Molecular Weight	411.35 g/mol
Synonyms	N(α)-Phosphoryl-Val-Trp; Phospho-Val-Tryptophan; Valine, N-[N-[N-(phosphono)-L-valyl]-L-tryptophyl]-; L-Tryptophan, N-[N-(phosphono)-L-valyl]-; N-Phosphono-L-valyl-L-tryptophan; Phosphonovalyltryptophan; 76166-64-8; Phosphorylated Val-Trp Dipeptide
EINECS	Contact for details

Quality Control

Our N(Alpha)-Phosphorylvalyltryptophan is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.