Description

Enkephalin-Leu, Acetaldehyde- is a chemically modified peptide derivative of the endogenous opioid peptide [Leu]enkephalin. This compound is of significant interest in biochemical and pharmacological research for studying opioid receptor interactions and signal transduction pathways. It serves as a critical intermediate and tool compound for neuroscientists and medicinal chemists developing novel neuroactive substances. Target industries include pharmaceutical R&D, academic research institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery.

Application

• Biochemical Research: Used as a reference standard and probe for investigating the structure-activity relationships (SAR) of enkephalin analogs and their binding to delta and mu opioid receptors.
• Medicinal Chemistry: Serves as a key synthetic intermediate or precursor in the development of novel peptide-based therapeutics targeting pain management and neurological disorders.
• Neuroscience Studies: Employed in vitro and in vivo studies to elucidate the role of enkephalinergic systems in analgesia, mood regulation, and addiction.
• Enzyme Substrate/Analysis: Potential use as a substrate for studying the activity of peptidases and other enzymes involved in neuropeptide metabolism.
• Diagnostic Development: Can be utilized in the development of immunoassays or other diagnostic tools for measuring enkephalin-related biomarkers.

Basic Information

Product Name	Enkephalin-Leu, Acetaldehyde-
CAS No.	76157-62-5
Molecular Formula	C30H41N5O7
Molecular Weight	583.68 g/mol
Synonyms	Acetaldehyde-Leu-Enkephalin; [Leu]Enkephalin, Acetaldehyde derivative; H-Tyr-Gly-Gly-Phe-Leu-CHO; N-Acetaldehyde-Leucine Enkephalin; Leu-Enkephalin Aldehyde; Opioid Peptide Analog; YGGFL-CHO; (5S,8S,11S,14S,17S)-5,14-Bis(4-hydroxyphenyl)-8,11-bis(2-methylpropyl)-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-6,9,12,15-tetraazaheptadecan-17-al
EINECS	Contact for details

Quality Control

Our Enkephalin-Leu, Acetaldehyde- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specification parameters to ensure the material meets the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.