Description

Angiotensin II, Lys(2)- is a synthetic peptide analog of the potent vasoconstrictor hormone Angiotensin II, specifically modified with a lysine substitution at position 2. This compound is a critical research-grade biochemical tool for studying the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and cardiovascular function. It is essential for pharmaceutical R&D, academic research in cardiovascular physiology, and the development of diagnostic assays targeting angiotensin receptors.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS) and its role in hypertension, heart failure, and kidney disease.
• Pharmacological Assays: Serves as a key agonist in receptor binding studies and functional assays (e.g., vascular contraction studies) to evaluate the potency and mechanism of action of angiotensin receptor blockers (ARBs) and other novel therapeutics.
• Diagnostic Development: Employed in the development and calibration of immunoassays (e.g., ELISA) for the detection and quantification of angiotensin-related peptides in biological samples.
• Cell Signaling Studies: Applied in vitro to stimulate angiotensin II type 1 (AT1) and type 2 (AT2) receptors to investigate downstream intracellular signaling pathways.
• Peptide Chemistry Reference: Acts as a well-characterized intermediate or analog in peptide synthesis research and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Angiotensin II, Lys(2)-
CAS No.	76018-51-4
Molecular Formula	C₅₀H₇₁N₁₃O₁₂
Molecular Weight	1046.2 g/mol
Synonyms	Lys(2)-Angiotensin II; [Lys²]-Angiotensin II; Asp-Arg-Val-Lys-Ile-His-Pro-Phe; Angiotensin II (2-Lys); H-Asp-Arg-Val-Lys-Ile-His-Pro-Phe-OH; DRVKYIHPF; Angiotensin II analog
EINECS	Contact for details

Quality Control

Our Angiotensin II, Lys(2)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.