Description

Enkephalin, n-Cyclo-Leu(5)- is a synthetic cyclic peptide analog of the endogenous opioid peptide enkephalin. This compound is of significant interest for its enhanced metabolic stability and receptor selectivity compared to linear peptides, making it a valuable research tool. It is primarily utilized by pharmaceutical researchers and life science companies investigating pain management, neurological disorders, and novel peptide-based therapeutics.

Application

• Neuroscience Research: As a stable analog for studying opioid receptor (δ and μ) binding, activation, and signaling pathways.
• Drug Discovery: Serving as a lead compound or reference standard in the development of new analgesic and neuroprotective agents.
• Biochemical Assays: Used in competitive binding assays, enzyme inhibition studies, and functional cellular tests.
• Pharmacology Studies: Investigating the physiological effects, metabolism, and structure-activity relationships (SAR) of opioid peptides.
• Academic Research: A key reagent for universities and institutes exploring the endogenous opioid system and peptide chemistry.
• Reference Standard: For quality control and analytical method development in peptide synthesis and characterization.

Basic Information

Product Name	Enkephalin, n-Cyclo-Leu(5)-
CAS No.	75975-40-5
Molecular Formula	C30H41N7O7
Molecular Weight	611.69 g/mol
Synonyms	Cyclo(Leu-enkephalin); Cyclo(Leu5-enkephalin); c-[Leu5]enkephalin; Cyclic Leu-enkephalin; Cyclic Leucine-enkephalin; H-Tyr-Gly-Gly-Phe-Leu- (cyclic 1→5); n-Cyclo-Leu(5)-Enkephalin
EINECS	Contact for details

Quality Control

Our Enkephalin, n-Cyclo-Leu(5)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity assessment. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.