Description

n-α,n-ε-Di-Fmoc-D-Lysine is a protected derivative of the non-natural D-isomer of the essential amino acid lysine, featuring dual 9-fluorenylmethoxycarbonyl (Fmoc) protecting groups. This compound is critically important as a high-purity building block for the solid-phase synthesis of peptides and peptidomimetics, particularly in the development of novel therapeutic agents and biochemical tools. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in advanced peptide chemistry, where stereochemical purity and reliable protection group strategy are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected D-lysine residue for the Fmoc/t-Bu strategy, enabling the controlled incorporation of D-amino acids into peptide chains.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, antimicrobial peptides (AMPs), and hormone analogs where D-amino acids enhance metabolic stability.
• Bioconjugation & Probe Development: Facilitates the site-specific introduction of functional handles via the orthogonal deprotection of the side-chain Fmoc group for labeling or linker attachment.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads with improved pharmacological profiles.
• Biochemical Tool Synthesis: Essential for creating enzyme substrates, inhibitors, and affinity ligands used in proteomics and molecular biology research.

Basic Information

Product Name	n-α,n-ε-Di-Fmoc-D-Lysine
CAS No.	75932-02-4
Molecular Formula	C36H34N2O6
Molecular Weight	590.67 g/mol
Synonyms	Nα,Nε-Bis(9-fluorenylmethoxycarbonyl)-D-lysine; D-Lysine, N2,N6-bis(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-D-Lys(Fmoc)-OH; N-α-Fmoc-N-ε-Fmoc-D-lysine; (2R)-6-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid; Di-Fmoc-D-lysine; N,N-Bis-Fmoc-D-lysine
EINECS	Contact for details

Quality Control

Our n-α,n-ε-Di-Fmoc-D-Lysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and stereochemical purity, consistent with standards for advanced pharmaceutical intermediates. Comprehensive Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances are provided to guarantee reliable performance in sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.