Description

Pepsinogen (1-12) is a specific peptide fragment derived from the N-terminal region of the zymogen pepsinogen, with the CAS registry number 75903-15-0. This compound is of significant value in biochemical research for studying the activation mechanism of pepsin and the structure-function relationships of aspartic proteases. It serves as a critical reference standard and substrate for researchers in pharmaceutical development, proteomics, and enzymology.

Application

• Biochemical Research: Used as a substrate or inhibitor in studies of pepsin and related aspartic protease enzymes to understand catalytic mechanisms and kinetics.
• Pharmaceutical Development: Serves as a key reference standard and tool compound in drug discovery programs targeting digestive enzymes and related disorders.
• Proteomics & Peptide Mapping: Employed in mass spectrometry and chromatography as a defined peptide standard for method calibration and protein sequencing analysis.
• Enzyme Activity Assays: Acts as a specific substrate in in vitro assays to measure pepsin activity or screen for potential enzyme modulators.
• Academic Research: Fundamental tool for university and institutional labs studying protein chemistry, zymogen activation, and peptide hormone precursors.
• Diagnostic Reagent Component: Potential use in the development of immunoassays or biochemical tests related to gastric function and pepsinogen levels.

Basic Information

Product Name	Pepsinogen (1-12)
CAS No.	75903-15-0
Molecular Formula	C58H89N17O19S
Molecular Weight	1352.5 g/mol
Synonyms	Pepsinogen fragment 1-12; Pepsinogen (1-12) peptide; L-Leucyl-L-seryl-L-glutaminyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-aspartyl-L-leucyl-L-threonyl-L-valyl-L-prolyl-L-cysteine; LSQNFKDLTVPC; Porcine Pepsinogen (1-12); Aspartic protease zymogen fragment 1-12
EINECS	Contact for details

Quality Control

Our Pepsinogen (1-12) is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere or desiccated conditions. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.