Description

Glucagon, N(Alpha)-Trinitrophenyl-His(1)-Homo-Arg(12)- is a chemically modified peptide analog of glucagon, designed for advanced biochemical and pharmacological research. This derivative is of significant value for studying glucagon receptor interactions, signal transduction pathways, and the development of novel diagnostic or therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in endocrinology, metabolic disease research, and peptide-based drug discovery.

Application

• Biochemical Research: Used as a specific probe or ligand in receptor binding assays and studies of glucagon action mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the research and development of new peptide-based therapeutics targeting metabolic disorders.
• Diagnostic Tool Development: Potential use in the development of immunoassays or other diagnostic tests for glucagon-related metabolic functions.
• Academic Research: Employed in university and institutional labs for fundamental studies in endocrinology, hormone signaling, and peptide chemistry.
• Structure-Activity Relationship (SAR) Studies: The specific modifications make it valuable for investigating how changes to the glucagon structure affect its biological activity and receptor affinity.

Basic Information

Product Name	Glucagon, N(Alpha)-Trinitrophenyl-His(1)-Homo-Arg(12)-
CAS No.	75881-61-7
Molecular Formula	C165H251N51O49S
Molecular Weight	~3666.2 g/mol
Synonyms	Nα-Trinitrophenyl-His1,homo-Arg12-Glucagon; TNP-His1,Har12-Glucagon; Glucagon (1-29), 1-[Nα-(2,4,6-trinitrophenyl)histidine], 12-homoarginine; Modified Glucagon Peptide; Glucagon Analog; Glucagon Derivative; Research Peptide 75881-61-7
EINECS	Contact for details

Quality Control

Our Glucagon, N(Alpha)-Trinitrophenyl-His(1)-Homo-Arg(12)- is produced and handled under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, related substances, and other critical parameters to ensure traceability and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized powder
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.