Description

2-Chloropyrimidine-4-Carbonitrile is a versatile and high-value heterocyclic building block, essential for advanced organic synthesis. Its reactive chloropyrimidine core and nitrile functionality make it a critical intermediate for constructing complex molecular architectures with precision. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a building block for creating functional polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical research.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the pyrimidine scaffold.
• Nucleophilic Substitution: The chlorine atom is readily displaced by various nucleophiles (amines, alkoxides) to create diverse pyrimidine libraries.

Basic Information

Product Name	2-Chloropyrimidine-4-Carbonitrile
CAS No.	75833-38-4
Molecular Formula	C5H2ClN3
Molecular Weight	139.54 g/mol
Synonyms	4-Cyano-2-chloropyrimidine; 2-Chloro-4-pyrimidinecarbonitrile; 2-Chloro-4-cyanopyrimidine; 2-Chloropyrimidine-4-carbonitrile; 4-Pyrimidinecarbonitrile, 2-chloro-; 2-Chloro-4-pyrimidine nitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Chloropyrimidine-4-Carbonitrile is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and batch-to-batch consistency to meet the stringent requirements of research and process development. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile by HPLC, NMR, and other relevant methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.