Description

Enkephalin Sulfonic Acid, Ala(2)-Nle(5)- is a chemically modified peptide analog of the endogenous opioid peptide enkephalin, designed for enhanced stability and research utility. This compound is critical for advanced biochemical and pharmacological research, particularly in studying opioid receptor interactions and signal transduction pathways without rapid enzymatic degradation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and peptide-based drug discovery.

Application

• Neuroscience Research: As a stable enkephalin analog for investigating the endogenous opioid system, receptor binding affinity, and neuronal signaling mechanisms.
• Pharmacological Studies: Used in vitro and in vivo to study analgesia, tolerance, and dependence related to opioid receptor activation.
• Biochemical Assay Development: Serves as a reference standard or active component in developing high-throughput screening assays for novel analgesic compounds.
• Peptide Chemistry & Drug Design: A key intermediate or model compound for designing and synthesizing new peptide therapeutics with improved metabolic stability.
• Academic & Institutional Research: Fundamental tool for university and government labs exploring neurochemistry, neuropharmacology, and peptide biology.

Basic Information

Product Name	Enkephalin Sulfonic Acid, Ala(2)-Nle(5)-
CAS No.	75829-10-6
Molecular Formula	C28H41N5O8S
Molecular Weight	607.72 g/mol
Synonyms	H-Tyr-Ala-Gly-Phe-Nle-OH (sulfonated); [Ala2, Nle5]-Enkephalin Sulfonic Acid; Norleucine5-Enkephalin Sulfonate; Ala(2)-Nle(5)-Enkephalin Sulfonic Acid; Opioid Peptide Analog; YAGFNle Sulfonic Acid; [Ala2,Nle5] Enkephalin Sulfonate; Modified Enkephalin Derivative
EINECS	Contact for details

Quality Control

Our Enkephalin Sulfonic Acid, Ala(2)-Nle(5)- is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.