Description

Glucagon, Thiol-Trp(2) CAS NO 75807-95-3 is a chemically modified peptide derivative of the hormone glucagon, featuring a thiol group and a tryptophan modification at position 2. This engineered structure is critical for advanced biochemical research and pharmaceutical development, particularly in studies of hormone-receptor interactions and metabolic pathways. It is an essential reagent for researchers and manufacturers in the fields of endocrinology, peptide-based drug discovery, and diagnostic assay development.

Application

• Pharmaceutical Research & Development: A key intermediate and reference standard in the development of novel glucagon analogs and peptide therapeutics targeting diabetes and metabolic disorders.
• Biochemical Assay Development: Used as a critical component in the development and validation of high-sensitivity immunoassays and receptor-binding studies.
• Metabolic Pathway Studies: Employed in academic and industrial research to investigate glucagon signaling, liver glucose metabolism, and related hormonal regulation.
• Conjugation & Labeling Chemistry: The thiol modification enables site-specific conjugation with fluorescent dyes, biotin, or other probes for creating diagnostic tools.
• Quality Control Reference Standard: Serves as a certified reference material (CRM) for the quality control and purity assessment of glucagon-related products in GMP environments.

Basic Information

Product Name	Glucagon, Thiol-Trp(2)
CAS No.	75807-95-3
Molecular Formula	C153H225N43O49S2
Molecular Weight	3484.8 g/mol (approx.)
Synonyms	Glucagon (1-29), Trp(2)-Thiol derivative; [Thiol-Trp2]-Glucagon; Thiolated Glucagon analog; Glucagon derivative modified at position 2; Glucagon thiol analog; HS-Trp2-Glucagon; Glucagon peptide research chemical
EINECS	Contact for details

Quality Control

Our Glucagon, Thiol-Trp(2) is produced under stringent quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.