Description

4-Chlorokynurenine is a specialized synthetic amino acid derivative and a key intermediate in neuropharmacological research. This compound matters as a crucial precursor for the synthesis of potent and selective glycine site antagonists of the NMDA receptor, enabling critical studies in neuroscience. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on developing treatments for neurological disorders and exploring excitatory neurotransmission pathways.

Application

• Pharmaceutical Intermediate: A vital precursor in the synthesis of advanced NMDA receptor glycine site antagonists, such as 7-chlorokynurenic acid and related analogs.
• Neuroscience Research: Used as a tool compound to study the role of the kynurenine pathway and NMDA receptor function in models of stroke, epilepsy, and chronic pain.
• Biochemical Standard: Serves as a reference standard in analytical methods (HPLC, LC-MS) for quantifying kynurenine pathway metabolites in biological samples.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop novel neuroprotective agents and modulators of glutamatergic signaling.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing high-value, research-grade neuroactive compounds.

Basic Information

Product Name	4-Chlorokynurenine
CAS No.	75802-84-5
Molecular Formula	C10H11ClN2O3
Molecular Weight	242.66 g/mol
Synonyms	4-Chloro-DL-kynurenine; (RS)-2-Amino-4-(2-chlorophenyl)-4-oxobutanoic acid; 2-Amino-4-(2-chlorobenzoyl)butanoic acid; 4-Chlorokynurenine; DL-4-Chlorokynurenine; 4-Cl-KYN; Kynurenine, 4-chloro-
EINECS	Contact for details

Quality Control

Our 4-Chlorokynurenine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.