Description

n-Acetyl-β-Endorphin CAS NO 75719-50-5 is a chemically modified, acetylated derivative of the endogenous neuropeptide β-endorphin. This modification enhances its metabolic stability and membrane permeability, making it a valuable research tool for studying opioid receptor pathways and pain modulation mechanisms. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, analgesic drug discovery, and peptide-based therapeutic development.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies investigating the endogenous opioid system, receptor binding affinity, and signal transduction.
• Analgesic Drug Discovery: Serves as a key biochemical tool for screening and evaluating novel analgesic compounds targeting mu-opioid receptors.
• Pharmacological Studies: Employed in vitro and in vivo to study the effects of acetylation on peptide stability, bioavailability, and duration of action.
• Biochemical Assay Development: Acts as a critical component in developing and validating ELISA, RIA, or other immunoassays for endorphin detection.
• Cell Signaling Research: Applied in cellular models to explore the role of β-endorphin in stress response, immune modulation, and behavioral effects.

Basic Information

Product Name	n-Acetyl-β-Endorphin
CAS No.	75719-50-5
Molecular Formula	C164H251N39O48
Molecular Weight	~3464.0 g/mol
Synonyms	Acetyl-β-Endorphin; N-Acetyl-β-Endorphin; N-Acetyl-β-Endorphin; Acetylated β-Endorphin; β-Endorphin (1-31), N-acetyl-; N-Acetyl-β-EP; N-Ac-β-EP; β-Lipotropin (61-91), N-acetyl-
EINECS	Contact for details

Quality Control

Our n-Acetyl-β-Endorphin is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.