Description

Neurotensin, Trp(11)- CAS NO 75644-95-0 is a synthetic peptide analog of the endogenous neuropeptide neurotensin, specifically modified at the 11th position with a tryptophan residue. This modification is significant for enhancing its stability and receptor-binding affinity, making it a valuable research tool for studying neurotensin receptor (NTS1 and NTS2) signaling pathways. It is primarily utilized by researchers and developers in the fields of neuroscience, pharmacology, and drug discovery for investigating conditions related to pain, schizophrenia, and cancer.

Application

• Neuroscience Research: A critical tool for studying the role of neurotensin in the central nervous system, including its effects on dopamine modulation, analgesia, and thermoregulation.
• Pharmacological Studies: Used in receptor binding assays and functional studies to characterize neurotensin receptor subtypes (NTS1/NTS2) and screen for potential agonists or antagonists.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design of novel neurotensin-based therapeutics targeting psychiatric disorders, pain management, and oncology.
• Biochemical Assays: Employed in cell-based assays and signal transduction studies to elucidate downstream effects of neurotensin receptor activation.
• Academic & Institutional Research: Essential for basic science research in university and government laboratories focused on peptide hormones and neuropeptide function.

Basic Information

Product Name	Neurotensin, Trp(11)- CAS NO 75644-95-0
CAS No.	75644-95-0
Molecular Formula	C₈₀H₁₂₂N₂₄O₂₁
Molecular Weight	1792.0 g/mol (approximate)
Synonyms	Neurotensin (8-13), Trp(11)-; [Trp11]-Neurotensin(8-13); H-Arg-Arg-Pro-Tyr-Ile-Trp-Leu-OH; Neurotensin Fragment 8-13, Trp(11)-; NT(8-13), Trp(11)-; pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Trp-Leu; [Trp11]NT(8-13); Neurotensin analog
EINECS	Contact for details

Quality Control

Our Neurotensin, Trp(11)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.