Description

Dynorphin (1-11), Ala(2)- is a specific, synthetic peptide fragment of the endogenous opioid peptide dynorphin A, modified with an alanine substitution at position 2. This compound is a critical research tool for studying the kappa opioid receptor (KOR) system, which is involved in pain modulation, stress response, and neuropsychiatric disorders. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biochemical researchers focused on neuropharmacology and peptide chemistry.

Application

• Neuroscience Research: As a selective ligand for investigating the structure, function, and signaling pathways of the kappa opioid receptor (KOR).
• Pain Mechanism Studies: Used in preclinical models to explore the role of dynorphin and KOR in pain perception and the development of novel analgesic targets.
• Neuropsychiatric Disorder Research: Applied in studies related to addiction, depression, and stress responses where the dynorphin/KOR system is implicated.
• Biochemical Assay Development: Serves as a reference standard or active component in receptor binding assays, functional cell-based assays, and signal transduction studies.
• Peptide Chemistry & Pharmacology: Used as a substrate for studying peptide-receptor interactions, stability, and metabolism.

Basic Information

Product Name	Dynorphin (1-11), Ala(2)-
CAS No.	75491-15-5
Molecular Formula	C58H88N16O15
Molecular Weight	1241.4 g/mol
Synonyms	Dynorphin A (1-11), Ala(2)-; [Ala2]-Dynorphin A (1-11); Tyr-Ala-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys; H-Tyr-Ala-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-OH; Dynorphin A 1-11 amide, Ala(2)- (variant); Kappa opioid receptor peptide ligand; Endogenous opioid peptide fragment
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Certificates of Analysis (COA) are provided with each batch, detailing purity, identity, and content. Standard quality control includes rigorous testing via HPLC for purity and MS for identity confirmation, ensuring compliance with research-grade specifications. We support custom synthesis to meet specific purity and quantity requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.