Description

1-Ethyl-6,8-Difluoro-1,4-Dihydro-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid is a high-purity advanced pharmaceutical intermediate, primarily known as a key synthetic precursor for the broad-spectrum fluoroquinolone antibiotic, lomefloxacin. Its value lies in enabling the production of critical antimicrobial agents with precise structural integrity and high biological activity. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors focused on active pharmaceutical ingredient (API) synthesis and advanced research.

Application

• Primary Pharmaceutical Intermediate: The critical building block for the synthesis of lomefloxacin hydrochloride, a third-generation fluoroquinolone antibiotic.
• API Development & Manufacturing: Used in the research, process development, and commercial-scale production of fluoroquinolone-based active pharmaceutical ingredients (APIs).
• Chemical Research & Synthesis: Serves as a versatile scaffold in medicinal chemistry for developing novel quinolone and fluoroquinolone derivatives with potential therapeutic applications.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Product Name	1-Ethyl-6,8-Difluoro-1,4-Dihydro-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid
CAS No.	75338-41-9
Molecular Formula	C17H19F2N3O3
Molecular Weight	351.35 g/mol
Synonyms	Lomefloxacin Intermediate; 1-Ethyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 7-(4-Methyl-1-piperazinyl)-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid; Lomefloxacin Carboxylic Acid; Lomefloxacin Acid; SC-47111 (Carboxylic Acid); (RS)-Lomefloxacin Carboxylic Acid; 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-
EINECS	Contact for details

Quality Control

Our 1-Ethyl-6,8-Difluoro-1,4-Dihydro-7-(4-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and supply chain needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.