Description

n-(n-Trifluoroacetyl-L-Cysteinyl)-Glycine Methyl Ester is a high-purity, protected peptide derivative designed for advanced chemical synthesis. This compound matters as a critical building block for the controlled introduction of cysteine residues in peptide and protein research, offering enhanced stability and reactivity. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories engaged in the development of novel therapeutic peptides, enzyme inhibitors, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of L-cysteine into peptide chains, where the trifluoroacetyl (TFA) group provides orthogonal protection.
• Bioconjugation & Protein Engineering: Used to introduce thiol-reactive handles or fluorescent labels onto peptides and proteins for diagnostic and therapeutic applications.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of cysteine-containing active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Biochemical Research: Employed in studies of enzyme mechanisms, protein folding, and disulfide bond formation due to its reactive cysteine moiety.
• Proteomics & Mass Spectrometry Standards: Utilized as a derivatization agent or a calibrant in analytical methods for peptide identification and quantification.
• Ligand Development: Acts as a scaffold for creating metal-chelating peptides or inhibitors targeting cysteine proteases.

Basic Information

Product Name	n-(n-Trifluoroacetyl-L-Cysteinyl)-Glycine Methyl Ester
CAS No.	75290-62-9
Molecular Formula	C8H11F3N2O4S
Molecular Weight	288.24 g/mol
Synonyms	N-(N-Trifluoroacetyl-L-cysteinyl)glycine methyl ester; L-Cysteine, N-[N-(trifluoroacetyl)glycyl]-, methyl ester; N-(Trifluoroacetylcysteinyl)glycine methyl ester; TFA-Cys-Gly-OMe; N-(N-Trifluoroacetyl-L-cysteinyl)glycine methyl ester; Methyl N-(N-trifluoroacetyl-L-cysteinyl)glycinate; Glycine, N-[N-(trifluoroacetyl)-L-cysteinyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our n-(n-Trifluoroacetyl-L-Cysteinyl)-Glycine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.