Description

(Met(O)27)-Glucagon (1-29) (Human, Bovine, Porcine) is a chemically modified, oxidized form of the glucagon peptide, specifically at the methionine-27 residue, with the CAS registry number 75217-63-9. This high-purity peptide reference standard is critical for advanced pharmaceutical research and quality control, enabling precise analytical method development and validation. It is an essential material for researchers and QC laboratories in the biopharmaceutical sector, particularly those focused on metabolic disorder therapeutics, peptide stability studies, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the identification, assay, and impurity testing of glucagon-based drug products in compliance with pharmacopeial monographs (USP, EP).
• Metabolic Research: A key tool in preclinical and clinical research investigating glucose metabolism, liver function, and the pathophysiology of diabetes.
• Analytical Method Development: Serves as a critical standard for developing and validating sensitive HPLC, LC-MS, and other chromatographic methods for peptide analysis.
• Impurity Profiling & Characterization: Used to study oxidation pathways and degradation products of glucagon, supporting drug stability and shelf-life studies.
• Quality Control & Batch Release: Essential for in-house QC testing of synthetic glucagon APIs and finished drug products to ensure identity, purity, and potency.
• Biomarker Studies: Potential application in proteomics and biomarker discovery related to pancreatic function and metabolic syndromes.

Basic Information

Product Name	(Met(O)27)-Glucagon (1-29) (Human, Bovine, Porcine)
CAS No.	75217-63-9
Molecular Formula	C153H225N43O49S
Molecular Weight	3483.8 g/mol
Synonyms	Glucagon (1-29), oxidized; Glucagon Oxidized at Met-27; [Met(O)27]-Glucagon; Oxidized Glucagon Fragment 1-29; Glucagon (ox); H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met(O)-Asn-Thr-OH; Glucagon Reference Standard (Oxidized)
EINECS	Contact for details

Quality Control

Our (Met(O)27)-Glucagon (1-29) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with stringent in-house specifications suitable for pharmaceutical research and development. We support audits and can provide additional documentation to meet GMP and ISO 9001 requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum confirms molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.