Description

3-(4-Methylphenyl)-1,1,1-Trifluoro-2-Propanone is a high-purity fluorinated aromatic ketone building block, essential for introducing the trifluoroacetyl group into complex molecular architectures. Its primary value lies in serving as a versatile and reactive synthon for the synthesis of advanced pharmaceutical intermediates and agrochemicals. This compound is particularly sought after by R&D chemists and process development scientists in the life sciences and specialty chemical industries for creating novel compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups for improved lipophilicity and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl moiety enhances efficacy and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display and lighting technologies.
• Advanced Polymer Chemistry: Employed to incorporate fluorine into polymer backbones or side chains, modifying properties like chemical resistance, thermal stability, and surface energy.
• Organic Synthesis & Catalysis Research: A valuable reagent in academic and industrial research for developing new fluorination methodologies and catalytic processes.
• Fluorinated Surfactant & Coating Additives: Used to synthesize specialty surfactants and surface modifiers that provide oil and water repellency.

Basic Information

Product Name	3-(4-Methylphenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	75199-80-3
Molecular Formula	C10H9F3O
Molecular Weight	202.17 g/mol
Synonyms	1-[4-Methylphenyl]-2,2,2-trifluoroethanone; 4-Methyl-α,α,α-trifluoroacetophenone; 4-Methylphenyl trifluoromethyl ketone; p-Methyl-α,α,α-trifluoroacetophenone; 4'-Methyl-2,2,2-trifluoroacetophenone; 2,2,2-Trifluoro-1-(4-methylphenyl)ethanone; 4-Methyl-α,α,α-trifluoroacetophenone; p-Tolyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our production of 3-(4-Methylphenyl)-1,1,1-Trifluoro-2-Propanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.