Description

H-Pro-Leu-Gly-Gly-Oh is a synthetic tetrapeptide derivative, consisting of the amino acids L-Proline, L-Leucine, and two Glycine residues. This compound is valued for its role as a key intermediate in advanced peptide synthesis and pharmaceutical research, where precise molecular structure is critical. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on creating novel bioactive peptides, enzyme substrates, or diagnostic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of more complex therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or model compound in enzymatic studies and proteomics research to understand peptide interactions.
• Cosmetic Peptide Synthesis: A potential precursor in the development of specialized bioactive peptides for advanced skincare formulations.
• Diagnostic Reagent Development: Employed in the creation of labeled peptides for assays and diagnostic kits.
• Academic & Industrial R&D: Fundamental material for method development in solid-phase and solution-phase peptide chemistry.

Basic Information

Product Name	H-Pro-Leu-Gly-Gly-Oh
CAS No.	75188-89-5
Molecular Formula	C17H29N5O5
Molecular Weight	383.44 g/mol
Synonyms	L-Prolyl-L-leucylglycylglycine; Pro-Leu-Gly-Gly; PLGG; H-Pro-Leu-Gly-Gly-OH; Tetrapeptide Pro-Leu-Gly-Gly; NSC 334910; (S)-2-((S)-1-((S)-2-((S)-2-Aminopropanamido)-3-methylbutanamido)-3-methylbutanamido)pyrrolidine-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our H-Pro-Leu-Gly-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and chiral purity analysis to ensure structural integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP guidelines for pharmaceutical intermediates and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.