Description

17 β-(Arylazido-β-Alanine)Estradiol-3-Methyl Ether is a specialized, photoactivatable derivative of estradiol, designed for advanced biochemical and pharmacological research. This compound is critical for studying estrogen receptor interactions and signaling pathways through photoaffinity labeling techniques. It serves as an essential tool for researchers and developers in the fields of endocrinology, molecular biology, and pharmaceutical discovery, enabling precise, covalent binding studies that are fundamental to drug design and mechanism elucidation.

Application

• Photoaffinity Labeling Probe: A key reagent for covalently tagging and identifying estrogen receptor binding sites in complex biological systems.
• Biochemical Research: Used in mechanistic studies to investigate estrogen receptor (ER) structure, function, and ligand interactions.
• Pharmaceutical R&D: Employed in the discovery and development of novel Selective Estrogen Receptor Modulators (SERMs) and other endocrine-targeting therapeutics.
• Molecular Biology Studies: Facilitates the mapping of protein-ligand interactions and the study of signal transduction pathways mediated by estrogen receptors.
• Proteomics and Target Identification: Acts as a molecular tool for identifying unknown proteins that bind to estrogen or its analogs.

Basic Information

Product Name	17 β-(Arylazido-β-Alanine)Estradiol-3-Methyl Ether
CAS No.	75179-82-7
Molecular Formula	C30H37N5O4
Molecular Weight	531.65 g/mol
Synonyms	17β-(Arylazido-β-Alanine)Estradiol 3-Methyl Ether; Estradiol-17β-(arylazido-β-alanine) 3-Methyl Ether; Photoaffinity Labeling Estradiol Derivative; 3-Methoxy-17β-[(4-azido-2,3,5,6-tetrafluorobenzoyl)amino]estra-1,3,5(10)-trien-17-ol (related structural descriptor); Arylazido Estradiol Analog; ER Photoaffinity Probe
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical reagent adheres to stringent quality protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and strictly light-sensitive nature, the material must be handled in a controlled environment to prevent decomposition. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.