Description

2-Mercapto-4-(4-Trifluoromethylphenyl)Pyrimidine is a specialized heterocyclic building block featuring a pyrimidine core substituted with a mercapto group and a trifluoromethylphenyl moiety. This compound is valued for its unique combination of a reactive thiol group and the electron-withdrawing, lipophilic trifluoromethyl group, making it a critical intermediate in advanced synthesis. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients, particularly in drug discovery and crop protection agent development.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands or monomers in the creation of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Utilized to develop molecular probes and labeling agents due to the reactive thiol functionality.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for fine chemical suppliers serving the custom synthesis market.

Basic Information

Product Name	2-Mercapto-4-(4-Trifluoromethylphenyl)Pyrimidine
CAS No.	75175-87-0
Molecular Formula	C11H7F3N2S
Molecular Weight	256.25 g/mol
Synonyms	4-(4-(Trifluoromethyl)phenyl)-2-pyrimidinethiol; 2-Mercapto-4-[4-(trifluoromethyl)phenyl]pyrimidine; 4-(4-Trifluoromethylphenyl)-2-mercaptopyrimidine; 2(1H)-Pyrimidinethione, 4-[4-(trifluoromethyl)phenyl]-; 2-Thioxo-4-(4-trifluoromethylphenyl)-1,2-dihydropyrimidine; 75175-87-0; 4-(α,α,α-Trifluoro-p-tolyl)-2-pyrimidinethiol
EINECS	Contact for details

Quality Control

Our 2-Mercapto-4-(4-Trifluoromethylphenyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.