Description

1,8-Naphthyridine-3-Carboxylic Acid, 1,4-Dihydro-1-Ethyl-6-Fluoro-4-Oxo-7-(1-Piperazinyl)-, Monomethanesulfonate is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial importance. Its core value lies in its role as a key building block for the synthesis of advanced fluoroquinolone antibiotics, where it imparts critical antibacterial properties. This compound is essential for manufacturers and research institutions in the pharmaceutical and fine chemical sectors focused on developing and producing next-generation antimicrobial agents. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final drug products.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of fluoroquinolone antibiotic APIs, such as enoxacin and analogous compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: Direct incorporation into the final chemical structure of broad-spectrum antibacterial drugs.
• Research & Development: Serves as a key scaffold in medicinal chemistry for designing and testing novel antibacterial agents with improved potency and safety profiles.
• Fine Chemical Production: Used in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.
• Reference Standard: Qualification as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Biochemical Research: Tool compound for studying bacterial DNA gyrase and topoisomerase IV inhibition mechanisms.

Basic Information

Item	Detail
Product Name	1,8-Naphthyridine-3-Carboxylic Acid, 1,4-Dihydro-1-Ethyl-6-Fluoro-4-Oxo-7-(1-Piperazinyl)-, Monomethanesulfonate
CAS No.	75167-06-5
Molecular Formula	C16H20FN3O3 • CH4O3S
Molecular Weight	401.42 g/mol
Synonyms	Enoxacin Mesylate; Enoxacin Methanesulfonate; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid methanesulfonate; AT-2266 Mesylate; CI-919 Mesylate; Flumark Mesylate; ENX Mesylate; 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-, monomethanesulfonate
EINECS	Contact for details

Quality Control

Our 1,8-Naphthyridine-3-Carboxylic Acid, 1,4-Dihydro-1-Ethyl-6-Fluoro-4-Oxo-7-(1-Piperazinyl)-, Monomethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets stringent specifications for pharmaceutical intermediates, with a typical purity of ≥98.0% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. Production can be aligned with cGMP guidelines as required for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.