Description

Leu-Enkephalin-Arg CAS NO 75106-70-6 is a synthetic peptide analog of the endogenous opioid peptide Leu-Enkephalin, extended at the C-terminus with an arginine residue. This modification enhances its stability and alters its receptor binding profile, making it a critical tool for advanced neuropharmacological and biochemical research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuroscience, pain management, and peptide hormone studies.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of opioid receptor subtypes (delta and mu), signal transduction, and neurotransmitter release.
• Biochemical Assay Development: Serves as a key substrate or competitor in the development of enzyme-linked immunosorbent assays (ELISA), radioimmunoassays (RIA), and receptor binding assays.
• Pharmacological Profiling: Essential for in vitro and ex vivo experiments to investigate the structure-activity relationships (SAR) of enkephalin analogs and their physiological effects.
• Peptide Chemistry & Drug Discovery: Acts as a building block or intermediate for the synthesis of more complex peptide-based drug candidates targeting the central nervous system.
• Academic & Clinical Research: Supports fundamental research into pain pathways, neuroprotection, and the role of endogenous opioids in various disease states.

Basic Information

Product Name	Leu-Enkephalin-Arg
CAS No.	75106-70-6
Molecular Formula	C34H50N10O8
Molecular Weight	726.83 g/mol
Synonyms	Leucine Enkephalin, Arg; [Arg6]-Leu-Enkephalin; Leu-Enkephalin-Arg6; H-Tyr-Gly-Gly-Phe-Leu-Arg-OH; L-Tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginine; YGGFLR; Opioid Peptide (Leu-Enkephalin, C-terminal Arg extension)
EINECS	Contact for details

Quality Control

Our Leu-Enkephalin-Arg is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation, to ensure it meets the exacting standards required for research applications. Certificates of Analysis (COA) detailing purity, chromatographic data, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.