Description

2-Propynal, 3-(4-Fluorophenyl)- (9Ci) is a specialized fluorinated alkyne derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its core value lies in enabling the construction of complex molecular architectures, particularly through click chemistry and cross-coupling reactions, due to its reactive terminal alkyne group. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who are developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing fluorinated drug candidates, leveraging the fluorine atom for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the fluorophenyl moiety is a critical structural feature.
• Click Chemistry Reagent: The terminal alkyne group makes it an ideal participant in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer functionalization.
• Material Science Research: Employed in the synthesis of advanced organic frameworks, conductive polymers, and specialty coatings that require fluorinated aromatic components.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to create complex conjugated systems.
• Chemical Biology Probes: Utilized to create fluorescent or affinity tags for studying biological processes and protein interactions.

Basic Information

Product Name	2-Propynal, 3-(4-Fluorophenyl)- (9Ci)
CAS No.	74929-23-0
Molecular Formula	C9H5FO
Molecular Weight	148.14 g/mol
Synonyms	3-(4-Fluorophenyl)propynal; 4-Fluorophenylpropiolaldehyde; (4-Fluorophenyl)propiolic aldehyde; 4-Fluorophenylpropiolic aldehyde; 3-(p-Fluorophenyl)propiolaldehyde; 1-Fluoro-4-(3-oxoprop-1-yn-1-yl)benzene; Propiolaldehyde, 3-(4-fluorophenyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Propynal, 3-(4-Fluorophenyl)- is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity confirmation, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity to oxidation and light, prolonged exposure to air or light should be avoided. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Light yellow to yellow solid or liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.