Description

Trt-His(Trt)-OH is a protected derivative of the amino acid L-Histidine, featuring trityl (Trt) protecting groups on both the imidazole side chain and the α-amino group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it provides essential orthogonality for the controlled assembly of complex peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the Fmoc/t-Bu strategy, enabling the incorporation of histidine residues into peptide chains.
• Pharmaceutical Research: For the synthesis of peptide drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation: Used in the preparation of peptide-protein conjugates or peptide-labeled compounds for diagnostic and research applications.
• Combinatorial Chemistry: Serves as a building block in libraries for high-throughput screening to discover new bioactive molecules.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and molecular biology.

Basic Information

Product Name	Trt-His(Trt)-OH
CAS No.	74853-62-6
Molecular Formula	C39H34N4O2
Molecular Weight	590.71 g/mol
Synonyms	Nα-Trityl-Nim-trityl-L-histidine; Nα-Trityl-Nim-tritylhistidine; Fmoc-His(Trt)-OH precursor; H-His(Trt)-OH (Nα-Trt protected); L-Histidine, N-[(trityloxy)methyl]-N-trityl-; Nα-Trityl-1-trityl-L-histidine; Protected L-Histidine derivative; Trt-His(Trt)
EINECS	Contact for details

Quality Control

Our Trt-His(Trt)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.