Description

Methyl 3-Fluoro-4-Formylbenzoate is a high-value fluorinated aromatic building block, specifically a benzoate ester bearing both formyl and fluorine substituents. This compound is critical for introducing key functional groups into complex molecular architectures, enabling precise chemical modifications in advanced synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic core for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine atom can improve pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, contributing to the development of advanced displays and lighting technologies.
• Cross-Coupling Reactions: The formyl group is amenable to further transformation (e.g., reductive amination, condensation), while the ester can be hydrolyzed, making it a versatile substrate for Suzuki, Heck, and other metal-catalyzed couplings.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and material chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates for client projects.

Basic Information

Product Name	Methyl 3-Fluoro-4-Formylbenzoate
CAS No.	74733-25-8
Molecular Formula	C9H7FO3
Molecular Weight	182.15 g/mol
Synonyms	3-Fluoro-4-formylbenzoic acid methyl ester; Methyl 3-fluoro-4-formylbenzoate; 4-Formyl-3-fluorobenzoic acid methyl ester; Benzoic acid, 3-fluoro-4-formyl-, methyl ester; Methyl 4-formyl-3-fluorobenzoate; 3-Fluoro-4-(methoxycarbonyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our Methyl 3-Fluoro-4-Formylbenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.